Optimization of integrated chromatography sequences for purification of biopharmaceuticals
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چکیده
منابع مشابه
Optimization of Dynamic Binding Capacity of Anion Exchange Chromatography Media for Recombinant Erythropoietin Purification
Background:The dynamic binding capacity (DBC) of a chromatography matrix in protein purification is the amount of the total protein absorbed into the matrix, before occurrence of a significant break in the breakthrough curve. Optimization of the process criteria for maximum DBC avoids extra process scale-up and reduces ...
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Biopharmaceuticals from microorganisms: from production to purification
The use of biopharmaceuticals dates from the 19th century and within 5-10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN α, β, and γ) and growth hormones. The production of biopharmaceuticals, known as bioprocess,...
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ژورنال
عنوان ژورنال: Biotechnology Progress
سال: 2019
ISSN: 8756-7938,1520-6033
DOI: 10.1002/btpr.2871